Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C62042
http://purl.obolibrary.org/obo/NCIT_C62042
Preferred Name

Leuprolide
Definitions
A synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression.
prefLabel
Leuprolide
label
Leuprolide
Has_Salt_Form
CHEBI_ID
CHEBI:6427
code
C62042
Has_Target
prefixIRI
NCIT:C62042
in_subset
Display_Name
Leuprolide
Preferred_Name
Leuprolide
FDA_UNII_Code
EFY6W0M8TG
Contributing_Source
CTRP
FDA
Chemical_Formula
C59H84N16O12
Maps_To
Leuprolide
CAS_Registry
53714-56-0
NSC Number
377526
Legacy Concept Name
Leuprolide_Base
type
ALT_DEFINITION
The active ingredient in a drug used to treat symptoms of advanced prostate cancer. It is also used to treat early puberty in children and certain gynecologic conditions. It is being studied in the treatment of other conditions and types of cancer. Leuprolide blocks the body from making testosterone (a male hormone) and estradiol (a female hormone). It may stop the growth of prostate cancer cells that need testosterone to grow. It is a type of gonadotropin-releasing hormone analog.
Is_Value_For_GDC_Property
subClassOf
Semantic_Type
Amino Acid, Peptide, or Protein
Pharmacologic Substance
UMLS_CUI
C0085272
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