loading...| Preferred Name | Epirubicin | |
| Synonyms |
|
|
| Definitions |
A 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C62028 |
|
| ALT_DEFINITION |
A drug used together with other drugs to treat early breast cancer that has spread to lymph nodes. It is also being studied in the treatment of other types of cancer. Epirubicin is a type of anthracycline antibiotic. |
|
| CAS_Registry |
56420-45-2 |
|
| CHEBI_ID |
CHEBI:47898 |
|
| Chemical_Formula |
C27H29NO11 |
|
| code |
C62028 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
A 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. |
|
| Display_Name |
Epirubicin |
|
| FDA_UNII_Code |
3Z8479ZZ5X |
|
| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| Is_Value_For_GDC_Property | ||
| label |
Epirubicin |
|
| Legacy Concept Name |
Epirubicin_Base |
|
| Maps_To |
Epirubicin |
|
| Preferred_Name |
Epirubicin |
|
| prefixIRI |
NCIT:C62028 |
|
| prefLabel |
Epirubicin |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0014582 |
|
| subClassOf |