Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C62028
http://purl.obolibrary.org/obo/NCIT_C62028
|
|---|---|
| Preferred Name | Epirubicin |
| Definitions |
A 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. |
|---|---|
| prefLabel | Epirubicin
|
| label | Epirubicin
|
| Has_Salt_Form | |
| CHEBI_ID | CHEBI:47898
|
| code | C62028
|
| prefixIRI | NCIT:C62028
|
| in_subset |
See more
See less
|
| Display_Name | Epirubicin
|
| Preferred_Name | Epirubicin
|
| FDA_UNII_Code | 3Z8479ZZ5X
|
| Contributing_Source |
CTRP
FDA
|
| Chemical_Formula | C27H29NO11
|
| Maps_To | Epirubicin
|
| CAS_Registry | 56420-45-2
|
| Legacy Concept Name | Epirubicin_Base
|
| type | |
| ALT_DEFINITION | A drug used together with other drugs to treat early breast cancer that has spread to lymph nodes. It is also being studied in the treatment of other types of cancer. Epirubicin is a type of anthracycline antibiotic.
|
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| UMLS_CUI | C0014582
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |