Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C61987
http://purl.obolibrary.org/obo/NCIT_C61987
Preferred Name

Trientine Hydrochloride
Definitions
The hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. Trientine chelates excess copper (Cu) ions in the body; the excess copper is subsequently removed from the body through the kidneys. As Cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 (SOD1), depletion of copper may inhibit the activation of signal transduction pathways required for cellular proliferation and angiogenesis. In addition, trientine may inhibit copper-induced secretion of interleukin-8 (IL-8).
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

The hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. Trientine chelates excess copper (Cu) ions in the body; the excess copper is subsequently removed from the body through the kidneys. As Cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 (SOD1), depletion of copper may inhibit the activation of signal transduction pathways required for cellular proliferation and angiogenesis. In addition, trientine may inhibit copper-induced secretion of interleukin-8 (IL-8).
prefLabel
Trientine Hydrochloride
label
Trientine Hydrochloride
PDQ_Closed_Trial_Search_ID
683662
code
C61987
prefixIRI
NCIT:C61987
in_subset
Display_Name
Trientine Hydrochloride
Preferred_Name
Trientine Hydrochloride
FDA_UNII_Code
HC3NX54582
Contributing_Source
CTRP
FDA
Chemical_Formula
C6H18N4.2HCl
Maps_To
Trientine Hydrochloride
CAS_Registry
38260-01-4
NCI_Drug_Dictionary_ID
683662
Legacy Concept Name
Trientine_Hydrochloride
Has_Free_Acid_Or_Base_Form
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
683662
Semantic_Type
Pharmacologic Substance
UMLS_CUI
C0770325
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