Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C61874
http://purl.obolibrary.org/obo/NCIT_C61874
Preferred Name

Palonosetron
Definitions
A carbazole derivative and a selective serotonin receptor antagonist with antiemetic activity. Palonosetron competitively blocks the action of serotonin at 5-hydroxytryptamine type 3 (5-HT3) receptors located on vagal afferents in the chemoreceptor trigger zone (CTZ), resulting in suppression of chemotherapy-induced nausea and vomiting. The CTZ is located in the area postrema on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle and outside the blood-brain barrier (BBB).
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A carbazole derivative and a selective serotonin receptor antagonist with antiemetic activity. Palonosetron competitively blocks the action of serotonin at 5-hydroxytryptamine type 3 (5-HT3) receptors located on vagal afferents in the chemoreceptor trigger zone (CTZ), resulting in suppression of chemotherapy-induced nausea and vomiting. The CTZ is located in the area postrema on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle and outside the blood-brain barrier (BBB).
label
Palonosetron
prefLabel
Palonosetron
Legacy Concept Name
Palonosetron
in_subset
Preferred_Name
Palonosetron
Chemical_Formula
C19H24N2O
Display_Name
Palonosetron
UMLS_CUI
C0220578
FDA_UNII_Code
5D06587D6R
prefixIRI
NCIT:C61874
Contributing_Source
CTRP
FDA
subClassOf
Has_Salt_Form
code
C61874
type
ALT_DEFINITION
The active ingredient in a drug used to treat nausea and vomiting caused by cancer treatment. Palonosetron is a type of serotonin receptor antagonist and a type of antiemetic.
Semantic_Type
Pharmacologic Substance
CAS_Registry
135729-56-5
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