loading...| Preferred Name |
Lithium Citrate |
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| Synonyms |
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|
| Definitions |
The citrate salt of lithium, a monovalent cation with antimanic activity. Although the exact mechanism is unclear, lithium might exert its mood-stabilizing effect via reduction of catecholamine concentration mediated through transneuronal membrane transport of sodium ion by sodium-potassium-stimulated adenosine triphosphatase (Na-K-ATPase). Alternatively, lithium may decrease cyclic adenosine monophosphate (cAMP) concentrations, which would desensitize hormonal-sensitive adenylyl cyclase receptors. Furthermore, lithium, in recommended dosage, blocks the activity of inositol-1-phosphatase, thereby resulting in the subsequent decrease of postsynaptic second messengers, diacylglycerol and inositol triphosphate, that contribute to chronic cell stimulation by altering electrical activity in the neuron. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C61812 |
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| CAS_Registry |
6080-58-6 |
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| CHEBI_ID |
CHEBI:64754 |
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| Chemical_Formula |
C6H5O7.3Li.4H2O |
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| code |
C61812 |
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| Contributing_Source |
FDA |
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| definition |
The citrate salt of lithium, a monovalent cation with antimanic activity. Although the exact mechanism is unclear, lithium might exert its mood-stabilizing effect via reduction of catecholamine concentration mediated through transneuronal membrane transport of sodium ion by sodium-potassium-stimulated adenosine triphosphatase (Na-K-ATPase). Alternatively, lithium may decrease cyclic adenosine monophosphate (cAMP) concentrations, which would desensitize hormonal-sensitive adenylyl cyclase receptors. Furthermore, lithium, in recommended dosage, blocks the activity of inositol-1-phosphatase, thereby resulting in the subsequent decrease of postsynaptic second messengers, diacylglycerol and inositol triphosphate, that contribute to chronic cell stimulation by altering electrical activity in the neuron. |
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| FDA_UNII_Code |
5Z6E9K79YV |
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| in_subset | ||
| label |
Lithium Citrate |
|
| Legacy Concept Name |
Lithium_Citrate |
|
| Preferred_Name |
Lithium Citrate |
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| prefixIRI |
NCIT:C61812 |
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| prefLabel |
Lithium Citrate |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0125997 |
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| subClassOf |