loading...| Preferred Name |
Hydrocortisone Acetate |
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| Synonyms |
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| Definitions |
The synthetic acetate ester form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties. Hydrocortisone acetate initially binds to the cytoplasmic glucocorticoid receptor; then the receptor-ligand complex is translocated to the nucleus where it initiates the transcription of genes encoding for anti-inflammatory mediators, such as cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C61785 |
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| CAS_Registry |
50-03-3 |
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| CHEBI_ID |
CHEBI:17609 |
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| Chemical_Formula |
C23H32O6 |
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| code |
C61785 |
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| Contributing_Source |
FDA |
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| definition |
The synthetic acetate ester form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties. Hydrocortisone acetate initially binds to the cytoplasmic glucocorticoid receptor; then the receptor-ligand complex is translocated to the nucleus where it initiates the transcription of genes encoding for anti-inflammatory mediators, such as cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes. |
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| FDA_UNII_Code |
3X7931PO74 |
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| in_subset | ||
| label |
Hydrocortisone Acetate |
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| Legacy Concept Name |
Hydrocortisone_Acetate |
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| Preferred_Name |
Hydrocortisone Acetate |
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| prefixIRI |
NCIT:C61785 |
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| prefLabel |
Hydrocortisone Acetate |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0063077 |
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| subClassOf |