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Biological and Environmental Research Ontology
| Preferred Name | Fluvastatin | |
| Synonyms |
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| Definitions |
A synthetic lipid-lowering agent with antilipidemic and potential antineoplastic properties. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated antigen-presenting cells such as human vascular endothelial cells. Due to its anti-inflammatory effects mediated by alterations of lipid metabolism, fluvastatin may possess chemopreventive and therapeutic antineoplastic properties. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C61768 |
|
| CAS_Registry |
93957-54-1
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|
| CHEBI_ID |
CHEBI:38561 CHEBI:5136
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| Chemical_Formula |
C24H26FNO4
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|
| code |
C61768
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| Contributing_Source |
FDA
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|
| definition |
A synthetic lipid-lowering agent with antilipidemic and potential antineoplastic properties. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated antigen-presenting cells such as human vascular endothelial cells. Due to its anti-inflammatory effects mediated by alterations of lipid metabolism, fluvastatin may possess chemopreventive and therapeutic antineoplastic properties.
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| FDA_UNII_Code |
4L066368AS
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| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Fluvastatin
|
|
| Legacy Concept Name |
Fluvastatin
|
|
| Maps_To |
Fluvastatin
|
|
| Preferred_Name |
Fluvastatin
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|
| prefixIRI |
NCIT:C61768
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|
| prefLabel |
Fluvastatin
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0082608
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| subClassOf |
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