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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C617
http://purl.obolibrary.org/obo/NCIT_C617
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|---|---|
| Preferred Name | Lomustine |
| Definitions |
A nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing. Lomustine is lipophilic and crosses the blood-brain barrier. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing. Lomustine is lipophilic and crosses the blood-brain barrier. (NCI04) |
|---|---|
| prefLabel | Lomustine
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| label | Lomustine
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| PDQ_Closed_Trial_Search_ID | 43065
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| code | C617
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| prefixIRI | NCIT:C617
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| in_subset |
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| Display_Name | Lomustine
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| Preferred_Name | Lomustine
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| FDA_UNII_Code | 7BRF0Z81KG
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C9H16ClN3O2
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| Maps_To | Lomustine
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| CAS_Registry | 13010-47-4
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| NSC Number | 79037
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| NCI_Drug_Dictionary_ID | 43065
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| Legacy Concept Name | Lomustine
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called alkylating agents.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 43065
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| Accepted_Therapeutic_Use_For | Brain tumors; Hodgkins disease
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0023972
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