Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Cyclophosphamide Anhydrous
Synonyms
Definitions

The anhydrous form of cyclophosphamide, a synthetic nitrogen mustard alkylating agent, with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to active metabolites including phosphoramide mustard, which binds to and crosslinks DNA and RNA, thereby inhibiting DNA replication and protein synthesis. This agent, at low doses, is also a potent immunosuppressant primarily by depleting T-regulatory cells.
ID

http://purl.obolibrary.org/obo/NCIT_C61694
CAS_Registry

50-18-0
CHEBI_ID

CHEBI:4027
Chemical_Formula

C7H15Cl2N2O2P
code

C61694
Contributing_Source

FDA
definition

The anhydrous form of cyclophosphamide, a synthetic nitrogen mustard alkylating agent, with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to active metabolites including phosphoramide mustard, which binds to and crosslinks DNA and RNA, thereby inhibiting DNA replication and protein synthesis. This agent, at low doses, is also a potent immunosuppressant primarily by depleting T-regulatory cells.
FDA_UNII_Code

6UXW23996M
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C177537

http://purl.obolibrary.org/obo/NCIT_C128784

http://purl.obolibrary.org/obo/NCIT_C157711

http://purl.obolibrary.org/obo/NCIT_C157712
Is_Value_For_GDC_Property

http://purl.obolibrary.org/obo/NCIT_C1909
label

Cyclophosphamide Anhydrous
Legacy Concept Name

Cyclophosphamide_Anhydrous
Maps_To

Cyclophosphamide Anhydrous
Preferred_Name

Cyclophosphamide Anhydrous
prefixIRI

NCIT:C61694
prefLabel

Cyclophosphamide Anhydrous
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C1880207
subClassOf

http://purl.obolibrary.org/obo/NCIT_C697

http://purl.obolibrary.org/obo/NCIT_C574
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