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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C61614
http://purl.obolibrary.org/obo/NCIT_C61614
|
|---|---|
| Preferred Name | Pemetrexed |
| Definitions |
A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. |
|---|---|
| label | Pemetrexed
|
| prefLabel | Pemetrexed
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| Legacy Concept Name | Pemetrexed_Base
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| in_subset |
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| Preferred_Name | Pemetrexed
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| Is_Value_For_GDC_Property | |
| Chemical_Formula | C20H21N5O6
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| Display_Name | Pemetrexed
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| Maps_To | Pemetrexed
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| Has_Target | |
| UMLS_CUI | C0210657
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| FDA_UNII_Code | 04Q9AIZ7NO
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| prefixIRI | NCIT:C61614
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| Contributing_Source |
CTRP
FDA
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| subClassOf | |
| CHEBI_ID | CHEBI:63616
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| Has_Salt_Form | |
| code | C61614
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| type | |
| NSC Number | 698037
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| CAS_Registry | 137281-23-3
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