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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C61592
http://purl.obolibrary.org/obo/NCIT_C61592
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|---|---|
| Preferred Name | Hodgkin's Antigens-GM-CSF-Expressing Cell Vaccine |
| Definitions |
An allogeneic vaccine consisting of Hodgkin lymphoma cells transfected with the granulocyte macrophage-colony-stimulating factor (GM-CSF) gene with potential antineoplastic activity. Upon vaccination, Hodgkin antigens-GM-CSF-expressing cell vaccine may stimulate a cytotoxic T-lymphocyte (CTL) immune response against Hodgkin lymphoma-associated antigens, which may result in the lysis of tumor cells expressing these antigens. In addition, transfected Hodgkin lymphoma cells secrete GM-CSF, which may potentiate the CTL response against Hodgkin lymphoma-associated antigens.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An allogeneic vaccine consisting of Hodgkin lymphoma cells transfected with the granulocyte macrophage-colony-stimulating factor (GM-CSF) gene with potential antineoplastic activity. Upon vaccination, Hodgkin antigens-GM-CSF-expressing cell vaccine may stimulate a cytotoxic T-lymphocyte (CTL) immune response against Hodgkin lymphoma-associated antigens, which may result in the lysis of tumor cells expressing these antigens. In addition, transfected Hodgkin lymphoma cells secrete GM-CSF, which may potentiate the CTL response against Hodgkin lymphoma-associated antigens. |
|---|---|
| prefLabel | Hodgkin's Antigens-GM-CSF-Expressing Cell Vaccine
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| label | Hodgkin's Antigens-GM-CSF-Expressing Cell Vaccine
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| PDQ_Closed_Trial_Search_ID | 445421
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| code | C61592
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| prefixIRI | NCIT:C61592
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| in_subset |
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| Display_Name | Hodgkin's Antigens-GM-CSF-Expressing Cell Vaccine
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| Preferred_Name | Hodgkin's Antigens-GM-CSF-Expressing Cell Vaccine
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| Contributing_Source | CTRP
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| Maps_To | Hodgkin's Antigens-GM-CSF-Expressing Cell Vaccine
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| NCI_Drug_Dictionary_ID | 445421
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| Legacy Concept Name | Hodgkin_s_Antigens-GM-CSF-Expressing_Cell_Vaccine
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 445421
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1831712
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