Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C61587
http://purl.obolibrary.org/obo/NCIT_C61587
Preferred Name

Danusertib
Definitions
A small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinases, which may result in cell growth arrest and apoptosis in tumor cells in which Aurora kinases are overexpressed. This agent may preferentially bind to and inhibit Aurora B kinase. Aurora kinases, a family of serine-threonine kinases, are important regulators of cellular proliferation and division.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinases, which may result in cell growth arrest and apoptosis in tumor cells in which Aurora kinases are overexpressed. This agent may preferentially bind to and inhibit Aurora B kinase. Aurora kinases, a family of serine-threonine kinases, are important regulators of cellular proliferation and division.
prefLabel
Danusertib
label
Danusertib
PDQ_Closed_Trial_Search_ID
489092
code
C61587
prefixIRI
NCIT:C61587
in_subset
Display_Name
Danusertib
Preferred_Name
Danusertib
FDA_UNII_Code
M3X659D0FY
Contributing_Source
CTRP
FDA
Chemical_Formula
C26H30N6O3
Maps_To
Danusertib
CAS_Registry
827318-97-8
NCI_Drug_Dictionary_ID
489092
Legacy Concept Name
PHA-739358
type
ALT_DEFINITION
A substance being studied in the treatment of chronic myelogenous leukemia. PHA-739358 may stop tumor growth by blocking certain enzymes needed for cancer cells to divide and causing them to die. It is a type of kinase inhibitor.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
489092
Semantic_Type
Pharmacologic Substance
UMLS_CUI
C2700603
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