Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C61568
http://purl.obolibrary.org/obo/NCIT_C61568
Preferred Name

Berubicin Hydrochloride
Definitions
The hydrochloride salt of the anthracycline derivative berubicin with potential antineoplastic activity. Berubicin intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, and RNA and protein synthesis. Unlike other anthracycline derivatives, this agent crosses the blood-brain barrier (BBB).
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

The hydrochloride salt of the anthracycline derivative berubicin with potential antineoplastic activity. Berubicin intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, and RNA and protein synthesis. Unlike other anthracycline derivatives, this agent crosses the blood-brain barrier (BBB).
label
Berubicin Hydrochloride
prefLabel
Berubicin Hydrochloride
Has_Free_Acid_Or_Base_Form
Legacy Concept Name
RTA_744
in_subset
Preferred_Name
Berubicin Hydrochloride
Is_Value_For_GDC_Property
Chemical_Formula
C34H35NO11.HCl
Display_Name
Berubicin Hydrochloride
Maps_To
Berubicin Hydrochloride
PDQ_Open_Trial_Search_ID
491929
Has_Target
FDA_UNII_Code
7BA3X03948
prefixIRI
NCIT:C61568
NCI_Drug_Dictionary_ID
491929
Contributing_Source
CTRP
FDA
subClassOf
code
C61568
type
ALT_DEFINITION
A substance being studied in the treatment of adult brain tumors. RTA 744 crosses the blood-brain barrier and blocks an enzyme needed for cancer growth. It is a type of topoisomerase inhibitor.
PDQ_Closed_Trial_Search_ID
491929
Semantic_Type
Pharmacologic Substance
CAS_Registry
293736-67-1
NCI_META_CUI
CL364772
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