Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C61566
http://purl.obolibrary.org/obo/NCIT_C61566
Preferred Name

Tubulin Binding Agent TTI-237
Definitions
A small synthetic molecule of triazolopyrimidine derivative with potential antitumor activity. With a novel mechanism of action distinct from the action of other vinca alkaloid compounds, TTI-237 specifically binds to tubulin at the vinca site, and promotes the polymerization of tubulin into microtubules. TTI-237 stabilizes tubulin and inhibits microtubule disassembly. This results in cell cycle arrest at the G2/M phase, and leading to cell death.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A small synthetic molecule of triazolopyrimidine derivative with potential antitumor activity. With a novel mechanism of action distinct from the action of other vinca alkaloid compounds, TTI-237 specifically binds to tubulin at the vinca site, and promotes the polymerization of tubulin into microtubules. TTI-237 stabilizes tubulin and inhibits microtubule disassembly. This results in cell cycle arrest at the G2/M phase, and leading to cell death.
prefLabel
Tubulin Binding Agent TTI-237
label
Tubulin Binding Agent TTI-237
PDQ_Closed_Trial_Search_ID
432958
code
C61566
Has_Target
prefixIRI
NCIT:C61566
in_subset
Preferred_Name
Tubulin Binding Agent TTI-237
Maps_To
Tubulin Binding Agent TTI-237
NCI_Drug_Dictionary_ID
432958
Legacy Concept Name
TTI-237
type
ALT_DEFINITION
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called mitotic inhibitors.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
432958
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C1831611
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