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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C61507
http://purl.obolibrary.org/obo/NCIT_C61507
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|---|---|
| Preferred Name | VEGFR2/PDGFR/c-Kit/Flt-3 Inhibitor SU014813 |
| Definitions |
An orally-active, tyrosine kinase receptor inhibitor with potential antitumor activity. SU014813 binds to and inhibits the phosphorylation of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor (PDGFR) alpha and beta, c-Kit and Fms-related tyrosine kinase 3 (Flt-3). This leads to an inhibition of cellular proliferation and angiogenesis and an induction of apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally-active, tyrosine kinase receptor inhibitor with potential antitumor activity. SU014813 binds to and inhibits the phosphorylation of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor (PDGFR) alpha and beta, c-Kit and Fms-related tyrosine kinase 3 (Flt-3). This leads to an inhibition of cellular proliferation and angiogenesis and an induction of apoptosis. |
|---|---|
| prefLabel | VEGFR2/PDGFR/c-Kit/Flt-3 Inhibitor SU014813
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| label | VEGFR2/PDGFR/c-Kit/Flt-3 Inhibitor SU014813
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| NCI_META_CUI | CL937294
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| PDQ_Closed_Trial_Search_ID | 486831
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| code | C61507
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| Has_Target |
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| prefixIRI | NCIT:C61507
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| in_subset | |
| Preferred_Name | VEGFR2/PDGFR/c-Kit/Flt-3 Inhibitor SU014813
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| FDA_UNII_Code | ZZ6VH5MZ17
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| Contributing_Source | FDA
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| Maps_To | VEGFR2/PDGFR/c-Kit/Flt-3 Inhibitor SU014813
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| CAS_Registry | 452105-23-6
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| NCI_Drug_Dictionary_ID | 486831
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| Legacy Concept Name | SU014813
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 486831
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| Semantic_Type | Pharmacologic Substance
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