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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C61493
http://purl.obolibrary.org/obo/NCIT_C61493
|
|---|---|
| Preferred Name | Gebasaxturev |
| Definitions |
A preparation of naturally occurring, oncolytic enterovirus, with potential antineoplastic activity. Upon administration, gebasaxturev targets and binds to intracellular adhesion molecule 1 (ICAM-1) and decay acceleration factor (DAF), both cell surface molecules that are overexpressed on certain malignant cells. After entering the cells, gebasaxturev replicates in these cancer cells, thereby causing cancer cell lysis. This results in a reduction of tumor cell growth.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A preparation of naturally occurring, oncolytic enterovirus, with potential antineoplastic activity. Upon administration, gebasaxturev targets and binds to intracellular adhesion molecule 1 (ICAM-1) and decay acceleration factor (DAF), both cell surface molecules that are overexpressed on certain malignant cells. After entering the cells, gebasaxturev replicates in these cancer cells, thereby causing cancer cell lysis. This results in a reduction of tumor cell growth. |
|---|---|
| prefLabel | Gebasaxturev
|
| label | Gebasaxturev
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| PDQ_Closed_Trial_Search_ID | 486330
|
| code | C61493
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| Has_Target | |
| prefixIRI | NCIT:C61493
|
| in_subset |
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| Display_Name | Gebasaxturev
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| Preferred_Name | Gebasaxturev
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| FDA_UNII_Code | 4B57CWT710
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| Contributing_Source |
CTRP
FDA
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| Maps_To |
Coxsackievirus A21
Coxsackievirus V937
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| CAS_Registry | 1802360-06-0
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| NCI_Drug_Dictionary_ID | 486330
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| Legacy Concept Name | Coxsackievirus_A21
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 486330
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| Semantic_Type |
Pharmacologic Substance
Virus
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| UMLS_CUI | C1440507
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