Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C61325
http://purl.obolibrary.org/obo/NCIT_C61325
|
|---|---|
| Preferred Name | Oligonucleotide SPC2996 |
| Definitions |
A synthetic antisense oligonucleotide against Bcl-2 messenger RNA with potential antitumor activity. Oligonucleotide SPC2996 binds to and inactivates Bcl-2 mRNA, thereby inhibiting the expression of Bcl-2 protein, promoting tumor cell apoptosis, and potentially enhancing the efficacy of standard cytotoxic chemotherapy. Linked to tumor drug resistance, the antiapoptotic protein Bcl-2 is upregulated in several types of cancers.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic antisense oligonucleotide against Bcl-2 messenger RNA with potential antitumor activity. Oligonucleotide SPC2996 binds to and inactivates Bcl-2 mRNA, thereby inhibiting the expression of Bcl-2 protein, promoting tumor cell apoptosis, and potentially enhancing the efficacy of standard cytotoxic chemotherapy. Linked to tumor drug resistance, the antiapoptotic protein Bcl-2 is upregulated in several types of cancers. |
|---|---|
| prefLabel | Oligonucleotide SPC2996
|
| label | Oligonucleotide SPC2996
|
| PDQ_Closed_Trial_Search_ID | 485272
|
| code | C61325
|
| prefixIRI | NCIT:C61325
|
| in_subset | |
| Preferred_Name | Oligonucleotide SPC2996
|
| Maps_To | Oligonucleotide SPC2996
|
| NCI_Drug_Dictionary_ID | 485272
|
| Legacy Concept Name | SPC2996_Oligonucleotide
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 485272
|
| Semantic_Type | Pharmacologic Substance
|
| UMLS_CUI | C1831825
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |