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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Recombinant Thyrotropin Alfa | |
| Synonyms |
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| Definitions |
A recombinant form of the human anterior pituitary glycoprotein thyroid stimulating hormone (TSH) with use in the diagnostic setting. With an amino acid sequence identical to that of human TSH, thyrotropin alfa binds to TSH receptors on normal thyroid epithelial cells or well-differentiated thyroid cancer cells, stimulating iodine uptake and organification, synthesis and secretion of thyroglobulin (Tg), triiodothyronine (T3), and thyroxine (T4). |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C61322 |
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| ALT_DEFINITION |
A form of thyroid-stimulating hormone (TSH) that is made in the laboratory. It is used to test for remaining or recurring cancer cells in patients who have been treated for thyroid cancer.
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| CAS_Registry |
194100-83-9
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| code |
C61322
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| Contributing_Source |
CTRP FDA
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| definition |
A recombinant form of the human anterior pituitary glycoprotein thyroid stimulating hormone (TSH) with use in the diagnostic setting. With an amino acid sequence identical to that of human TSH, thyrotropin alfa binds to TSH receptors on normal thyroid epithelial cells or well-differentiated thyroid cancer cells, stimulating iodine uptake and organification, synthesis and secretion of thyroglobulin (Tg), triiodothyronine (T3), and thyroxine (T4).
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| Display_Name |
Recombinant Thyrotropin Alfa
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| FDA_UNII_Code |
AVX3D5A4LM
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Recombinant Thyrotropin Alfa
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| Legacy Concept Name |
Recombinant_Thyrotropin_Alfa
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| Maps_To |
Recombinant Thyrotropin Alfa
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| NCI_Drug_Dictionary_ID |
481277
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| PDQ_Closed_Trial_Search_ID |
481277
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| PDQ_Open_Trial_Search_ID |
481277
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| Preferred_Name |
Recombinant Thyrotropin Alfa
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| prefixIRI |
NCIT:C61322
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| prefLabel |
Recombinant Thyrotropin Alfa
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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| UMLS_CUI |
C2587204
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| subClassOf |
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| Mapping To | Ontology | Source |
|---|---|---|
| http://purl.bioontology.org/ontology/PDQ/CDR0000481277 | PDQ | LOOM |
| http://purl.bioontology.org/ontology/PDQ/CDR0000481277 | PDQ | LOOM |
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61322 | NCIT | LOOM |