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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C61322
http://purl.obolibrary.org/obo/NCIT_C61322
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|---|---|
| Preferred Name | Recombinant Thyrotropin Alfa |
| Definitions |
A recombinant form of the human anterior pituitary glycoprotein thyroid stimulating hormone (TSH) with use in the diagnostic setting. With an amino acid sequence identical to that of human TSH, thyrotropin alfa binds to TSH receptors on normal thyroid epithelial cells or well-differentiated thyroid cancer cells, stimulating iodine uptake and organification, synthesis and secretion of thyroglobulin (Tg), triiodothyronine (T3), and thyroxine (T4).
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A recombinant form of the human anterior pituitary glycoprotein thyroid stimulating hormone (TSH) with use in the diagnostic setting. With an amino acid sequence identical to that of human TSH, thyrotropin alfa binds to TSH receptors on normal thyroid epithelial cells or well-differentiated thyroid cancer cells, stimulating iodine uptake and organification, synthesis and secretion of thyroglobulin (Tg), triiodothyronine (T3), and thyroxine (T4). |
|---|---|
| prefLabel | Recombinant Thyrotropin Alfa
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| label | Recombinant Thyrotropin Alfa
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| PDQ_Closed_Trial_Search_ID | 481277
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| code | C61322
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| Has_Target | |
| prefixIRI | NCIT:C61322
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| in_subset |
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| Display_Name | Recombinant Thyrotropin Alfa
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| Preferred_Name | Recombinant Thyrotropin Alfa
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| FDA_UNII_Code | AVX3D5A4LM
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Recombinant Thyrotropin Alfa
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| CAS_Registry | 194100-83-9
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| NCI_Drug_Dictionary_ID | 481277
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| Legacy Concept Name | Recombinant_Thyrotropin_Alfa
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| type | |
| ALT_DEFINITION | A form of thyroid-stimulating hormone (TSH) that is made in the laboratory. It is used to test for remaining or recurring cancer cells in patients who have been treated for thyroid cancer.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 481277
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C2587204
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