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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C61311
http://purl.obolibrary.org/obo/NCIT_C61311
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|---|---|
| Preferred Name | B-Raf/VEGFR-2 Inhibitor RAF265 |
| Definitions |
An orally bioavailable small molecule with potential antineoplastic activity. CHIR-265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR-2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are frequently upregulated in neoplasms.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable small molecule with potential antineoplastic activity. CHIR-265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR-2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are frequently upregulated in neoplasms. |
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| prefLabel | B-Raf/VEGFR-2 Inhibitor RAF265
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| label | B-Raf/VEGFR-2 Inhibitor RAF265
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| PDQ_Closed_Trial_Search_ID | 484456
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| code | C61311
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| Has_Target | |
| prefixIRI | NCIT:C61311
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| in_subset |
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| Display_Name | B-Raf/VEGFR-2 Inhibitor RAF265
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| Preferred_Name | B-Raf/VEGFR-2 Inhibitor RAF265
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| FDA_UNII_Code | 8O434L3768
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| Contributing_Source |
CTRP
FDA
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| Maps_To | B-Raf/VEGFR-2 Inhibitor RAF265
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| CAS_Registry | 927880-90-8
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| NCI_Drug_Dictionary_ID | 484456
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| Legacy Concept Name | CHIR-265
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of melanoma. CHIR-265 may block the growth of tumors and the growth of blood vessels from surrounding tissue to the tumor. It is a type of Raf kinase inhibitor and angiogenesis inhibitor.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 484456
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1831810
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