Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C61306 http://purl.obolibrary.org/obo/NCIT_C61306
Preferred Name	Amonafide L-Malate
Definitions	The malate salt of amonafide, an imide derivative of naphthalic acid, with potential antineoplastic activity. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in DNA double-strand breaks (DSB) and inhibition of DNA replication and RNA synthesis.
Type	http://www.w3.org/2002/07/owl#Class

definition	The malate salt of amonafide, an imide derivative of naphthalic acid, with potential antineoplastic activity. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in DNA double-strand breaks (DSB) and inhibition of DNA replication and RNA synthesis.
prefLabel	Amonafide L-Malate
label	Amonafide L-Malate
PDQ_Closed_Trial_Search_ID	485171
code	C61306
prefixIRI	NCIT:C61306
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Display_Name	Amonafide L-Malate
Preferred_Name	Amonafide L-Malate
FDA_UNII_Code	LI06Q37TEG
Contributing_Source	CTRP FDA
Chemical_Formula	C16H17N3O2.C4H6O5
Maps_To	Amonafide L-Malate
CAS_Registry	618863-54-0
NCI_Drug_Dictionary_ID	485171
Legacy Concept Name	Amonafide_L-Malate
Has_Free_Acid_Or_Base_Form	http://purl.obolibrary.org/obo/NCIT_C71628
type	http://www.w3.org/2002/07/owl#Class
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C582
PDQ_Open_Trial_Search_ID	485171
Accepted_Therapeutic_Use_For	Treatment of secondary acute myeloid leukemia
Semantic_Type	Pharmacologic Substance
UMLS_CUI	C1879697

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