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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C61104
http://purl.obolibrary.org/obo/NCIT_C61104
|
|---|---|
| Preferred Name | TLR7 Agonist 852A |
| Definitions |
A synthetic imidazoquinoline Toll-like receptor 7 (TLR7) agonist with immunostimulating and potential antitumor activities. TLR7 agonist 852A binds to and activates TLR7, thereby stimulating plasmacytoid dendritic cells (pDC) through the TLR7-MyD88-dependent signaling pathway. Activation of pDC results in secretion of interferon alpha, the production of proimflammatory cytokines, the upregulation of co-stimulatory molecules, and enhanced T and B-cell stimulatory responses.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic imidazoquinoline Toll-like receptor 7 (TLR7) agonist with immunostimulating and potential antitumor activities. TLR7 agonist 852A binds to and activates TLR7, thereby stimulating plasmacytoid dendritic cells (pDC) through the TLR7-MyD88-dependent signaling pathway. Activation of pDC results in secretion of interferon alpha, the production of proimflammatory cytokines, the upregulation of co-stimulatory molecules, and enhanced T and B-cell stimulatory responses. |
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| prefLabel | TLR7 Agonist 852A
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| label | TLR7 Agonist 852A
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| PDQ_Closed_Trial_Search_ID | 396824
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| code | C61104
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| prefixIRI | NCIT:C61104
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| in_subset | |
| Preferred_Name | TLR7 Agonist 852A
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| FDA_UNII_Code | 6PJC3KPK6S
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| Contributing_Source | FDA
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| Maps_To | TLR7 Agonist 852A
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| CAS_Registry | 532959-63-0
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| NCI_Drug_Dictionary_ID | 396824
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| Legacy Concept Name | _852A
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of certain adult and childhood blood cancers and other types of cancer. 852A may help the patient's immune system block tumor growth. It is a type of immune system modulator.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 396824
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C1541384
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