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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C61095
http://purl.obolibrary.org/obo/NCIT_C61095
|
|---|---|
| Preferred Name | Ecromeximab |
| Definitions |
A low-fucose, human-mouse chimeric IgG1 monoclonal antibody with potential antineoplastic activity targeting at the ganglioside GD3, a surface antigen expressed on many malignant melanoma cells. Monoclonal antibody KW-2871 binds to GD3-positive cells, thereby initiating antibody-dependent cytotoxicity against GD3-positive cells. This agent is prepared by fusing murine immunoglobulin (Ig) light and heavy variable regions derived from the murine IgG3 antibody KM-641 to a human constant (Fc) region. The low fucose content of the oligosaccharide side chains of this antibody may enhance binding of the antibody Fc region to lymphocyte Fc receptors.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A low-fucose, human-mouse chimeric IgG1 monoclonal antibody with potential antineoplastic activity targeting at the ganglioside GD3, a surface antigen expressed on many malignant melanoma cells. Monoclonal antibody KW-2871 binds to GD3-positive cells, thereby initiating antibody-dependent cytotoxicity against GD3-positive cells. This agent is prepared by fusing murine immunoglobulin (Ig) light and heavy variable regions derived from the murine IgG3 antibody KM-641 to a human constant (Fc) region. The low fucose content of the oligosaccharide side chains of this antibody may enhance binding of the antibody Fc region to lymphocyte Fc receptors. |
|---|---|
| prefLabel | Ecromeximab
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| label | Ecromeximab
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| PDQ_Closed_Trial_Search_ID | 467926
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| code | C61095
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| Has_Target | |
| prefixIRI | NCIT:C61095
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| in_subset |
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| Display_Name | Ecromeximab
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| Preferred_Name | Ecromeximab
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| FDA_UNII_Code | M76FX2JZRM
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Ecromeximab
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| CAS_Registry | 292819-64-8
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| NCI_Drug_Dictionary_ID | 467926
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| Legacy Concept Name | Monoclonal_Antibody_KW-2871
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 467926
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Immunologic Factor
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| UMLS_CUI | C1669509
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