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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C61071
http://purl.obolibrary.org/obo/NCIT_C61071
|
|---|---|
| Preferred Name | Aerosolized Liposomal Rubitecan |
| Definitions |
An aerosolized liposomal preparation of rubitecan, a water-insoluble derivative of camptothecin with potential antineoplastic activity. Rubitecan (or 9-nitro-20 (S)-camptothecin) and its active metabolite 9-aminocamptothecin (9-AC) selectively stabilize topoisomerase I-DNA covalent complexes during S-phase, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. This agent is formulated with dilauroylphosphatidylcholine and nebulized in particle sizes of 1.2-1.6 micrometer mass median aerodynamic diameter.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An aerosolized liposomal preparation of rubitecan, a water-insoluble derivative of camptothecin with potential antineoplastic activity. Rubitecan (or 9-nitro-20 (S)-camptothecin) and its active metabolite 9-aminocamptothecin (9-AC) selectively stabilize topoisomerase I-DNA covalent complexes during S-phase, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. This agent is formulated with dilauroylphosphatidylcholine and nebulized in particle sizes of 1.2-1.6 micrometer mass median aerodynamic diameter. |
|---|---|
| prefLabel | Aerosolized Liposomal Rubitecan
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| label | Aerosolized Liposomal Rubitecan
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| PDQ_Closed_Trial_Search_ID | 473242
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| code | C61071
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| prefixIRI | NCIT:C61071
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| in_subset | |
| Preferred_Name | Aerosolized Liposomal Rubitecan
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| Maps_To | Aerosolized Liposomal Rubitecan
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| NCI_Drug_Dictionary_ID | 473242
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| Legacy Concept Name | Aerosolized_Liposomal_9-Nitrocamptothecin
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 473242
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1831773
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