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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C60779
http://purl.obolibrary.org/obo/NCIT_C60779
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|---|---|
| Preferred Name | Pazopanib Hydrochloride |
| Definitions |
The hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated. |
|---|---|
| prefLabel | Pazopanib Hydrochloride
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| label | Pazopanib Hydrochloride
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| PDQ_Closed_Trial_Search_ID | 476479
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| code | C60779
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| Has_Target | |
| prefixIRI | NCIT:C60779
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| in_subset |
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| Display_Name | Pazopanib Hydrochloride
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| Preferred_Name | Pazopanib Hydrochloride
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| FDA_UNII_Code | 33Y9ANM545
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C21H23N7O2S.HCl
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| Maps_To | Pazopanib Hydrochloride
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| CAS_Registry | 635702-64-6
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| NSC Number | 737754
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| NCI_Drug_Dictionary_ID | 476479
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| Legacy Concept Name | Pazopanib
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| ALT_DEFINITION | A drug that is used to treat kidney cancer and is being studied in the treatment of other types of cancer. It may prevent the growth of new blood vessels that tumors need to grow. It is a type of protein tyrosine kinase inhibitor and a type of antiangiogenesis agent.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 476479
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1872226
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