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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C60772
http://purl.obolibrary.org/obo/NCIT_C60772
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|---|---|
| Preferred Name | Hedgehog Inhibitor IPI-609 |
| Definitions |
A novel proprietary small molecule, and a selective inhibitor of sonic hedgehog signaling pathway, with potential anti-tumor activity. The hedgehog signaling pathway is normally active during neuronal development in embryos and quiescent in adult cells. However, aberrant activation of the hedgehog pathway in adults has been implicated in many cancers, including cancers of the pancreas, prostate, lung (small cell), and brain (glioma). IPI-609 exerts its effect through inhibiting the hedgehog signaling pathway and thereby alters gene expressions of the cancer cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A novel proprietary small molecule, and a selective inhibitor of sonic hedgehog signaling pathway, with potential anti-tumor activity. The hedgehog signaling pathway is normally active during neuronal development in embryos and quiescent in adult cells. However, aberrant activation of the hedgehog pathway in adults has been implicated in many cancers, including cancers of the pancreas, prostate, lung (small cell), and brain (glioma). IPI-609 exerts its effect through inhibiting the hedgehog signaling pathway and thereby alters gene expressions of the cancer cells. |
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| prefLabel | Hedgehog Inhibitor IPI-609
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| label | Hedgehog Inhibitor IPI-609
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| code | C60772
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| Has_Target | |
| prefixIRI | NCIT:C60772
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| in_subset | |
| Preferred_Name | Hedgehog Inhibitor IPI-609
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| FDA_UNII_Code | 0E0K1H745W
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| Contributing_Source | FDA
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| Maps_To | Hedgehog Inhibitor IPI-609
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| CAS_Registry | 878204-96-7
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| Legacy Concept Name | IPI-609
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1881124
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