Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C60770
http://purl.obolibrary.org/obo/NCIT_C60770
Preferred Name

Obatoclax
Definitions
A small molecule and a pan-inhibitor of Bcl-2 family proteins, with pro-apoptotic activity. GX015-070 is a selective antagonist of the BH3-binding groove of the Bcl-2 family proteins, which are frequently overexpressed in cancers including chronic lymphocytic leukemia (CLL). This agent induces/restores apoptosis in cancer cells by inhibiting apoptosis suppressors in multiple members of the Bcl-2 family simultaneously.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A small molecule and a pan-inhibitor of Bcl-2 family proteins, with pro-apoptotic activity. GX015-070 is a selective antagonist of the BH3-binding groove of the Bcl-2 family proteins, which are frequently overexpressed in cancers including chronic lymphocytic leukemia (CLL). This agent induces/restores apoptosis in cancer cells by inhibiting apoptosis suppressors in multiple members of the Bcl-2 family simultaneously.
prefLabel
Obatoclax
label
Obatoclax
Has_Salt_Form
code
C60770
Has_Target
prefixIRI
NCIT:C60770
in_subset
Preferred_Name
Obatoclax
FDA_UNII_Code
QN4128B52A
Contributing_Source
FDA
Chemical_Formula
C20H19N3O
CAS_Registry
803712-67-6
NSC Number
729280
Legacy Concept Name
GX015-070
PubMedID_Primary_Reference
19118042
type
ALT_DEFINITION
A substance being studied in the treatment of several types of cancer. Obatoclax blocks the actions of certain proteins that cells need to live and it may kill cancer cells. It is a type of apoptosis inducer, a BCL2 protein antagonist, and a BH3 mimetic.
subClassOf
Semantic_Type
Pharmacologic Substance
UMLS_CUI
C2713011
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