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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C607
http://purl.obolibrary.org/obo/NCIT_C607
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|---|---|
| Preferred Name | Leucovorin Calcium |
| Definitions |
An active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. (NCI04) |
|---|---|
| prefLabel | Leucovorin Calcium
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| label | Leucovorin Calcium
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| PDQ_Closed_Trial_Search_ID | 42584
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| code | C607
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| prefixIRI | NCIT:C607
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| in_subset |
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| Display_Name | Leucovorin Calcium
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| Preferred_Name | Leucovorin Calcium
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| FDA_UNII_Code | RPR1R4C0P4
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Leucovorin Calcium
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| CAS_Registry | 1492-18-8
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| NSC Number | 3590
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| NCI_Drug_Dictionary_ID | 42584
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| Legacy Concept Name | Leucovorin_Calcium
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| ALT_DEFINITION | A drug used to lessen the toxic effects of substances that block the action of folic acid, especially the anticancer drug methotrexate. Leucovorin calcium is used to treat some types of anemia and is also used with fluorouracil to treat colorectal cancer. It is also being studied in the treatment of other types of cancer and other conditions. Leucovorin calcium is a form of folic acid. It is a type of chemoprotective agent and a type of chemosensitizing agent.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42584
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| Accepted_Therapeutic_Use_For | Megaloblastic anemia due to folate deficiency; Enhanced fluorouracil inhibition of thymidylate synthase; Reverse dihydrofolate reductase inhibition by methotrexate; Folic acid antagonist overdose; Nitrous Oxide toxicity
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0731033
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