Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C605
http://purl.obolibrary.org/obo/NCIT_C605
|
|---|---|
| Preferred Name | Ketoconazole |
| Definitions |
A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04)
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04) |
|---|---|
| prefLabel | Ketoconazole
|
| label | Ketoconazole
|
| CHEBI_ID | CHEBI:47519
|
| PDQ_Closed_Trial_Search_ID | 39488
|
| code | C605
|
| prefixIRI | NCIT:C605
|
| in_subset |
See more
See less
|
| Display_Name | Ketoconazole
|
| Preferred_Name | Ketoconazole
|
| FDA_UNII_Code | R9400W927I
|
| Contributing_Source |
CTRP
FDA
|
| Chemical_Formula | C26H28Cl2N4O4
|
| Maps_To | Ketoconazole
|
| CAS_Registry | 65277-42-1
|
| NSC Number | 317629
|
| NCI_Drug_Dictionary_ID | 39488
|
| Legacy Concept Name | Ketoconazole
|
| type | |
| ALT_DEFINITION | A drug that treats infection caused by a fungus. It is also used as a treatment for prostate cancer because it can block the production of male sex hormones.
|
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39488
|
| Accepted_Therapeutic_Use_For | Seborrheic Dermatitis; Prostate cancer
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
|
| UMLS_CUI | C0022625
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |