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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C603
http://purl.obolibrary.org/obo/NCIT_C603
|
|---|---|
| Preferred Name | Isotretinoin |
| Definitions |
A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization. |
|---|---|
| prefLabel | Isotretinoin
|
| label | Isotretinoin
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| CHEBI_ID | CHEBI:6067
|
| PDQ_Closed_Trial_Search_ID | 42657
|
| code | C603
|
| Has_Target | |
| prefixIRI | NCIT:C603
|
| in_subset |
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| Display_Name | Isotretinoin
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| Preferred_Name | Isotretinoin
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| FDA_UNII_Code | EH28UP18IF
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C20H28O2
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| Maps_To | Isotretinoin
|
| CAS_Registry | 4759-48-2
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| NSC Number | 329481
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| NCI_Drug_Dictionary_ID | 42657
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| Legacy Concept Name | Isotretinoin
|
| type | |
| ALT_DEFINITION | A drug that is used in the treatment of acne and psoriasis and is being studied in cancer prevention. It is a type of retinoid.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42657
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| Accepted_Therapeutic_Use_For | Severe recalcitrant nodular acne; psoriasis; cornification disorders; cutaneous T-cell lymphoma; juvenile metastatic neuroblastoma and leukemia
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0022265
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