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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C596
http://purl.obolibrary.org/obo/NCIT_C596
|
|---|---|
| Preferred Name | Ionomycin |
| Definitions |
A polyether antibiotic isolated from Streptomyces conglobatus sp. nov. Trejo with antineoplastic activity. Ionomycin is a calcium ionophore that increases intracellular Ca++ levels, possibly relating to endonuclease activation of lymphocytes and decreased ratio of Bcl-2 to Bax and ultimately apoptosis. In addition, this agent is used to investigate the role of intracellular calcium in cellular processes. (NCI)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A polyether antibiotic isolated from Streptomyces conglobatus sp. nov. Trejo with antineoplastic activity. Ionomycin is a calcium ionophore that increases intracellular Ca++ levels, possibly relating to endonuclease activation of lymphocytes and decreased ratio of Bcl-2 to Bax and ultimately apoptosis. In addition, this agent is used to investigate the role of intracellular calcium in cellular processes. (NCI) |
|---|---|
| prefLabel | Ionomycin
|
| label | Ionomycin
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| CHEBI_ID | CHEBI:63954
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| PDQ_Closed_Trial_Search_ID | 43046
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| code | C596
|
| prefixIRI | NCIT:C596
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| in_subset | |
| Preferred_Name | Ionomycin
|
| FDA_UNII_Code | 54V905V6AT
|
| Contributing_Source | FDA
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| Maps_To | Ionomycin
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| CAS_Registry | 56092-81-0
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| NCI_Drug_Dictionary_ID | 43046
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| Legacy Concept Name | Ionomycin
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 43046
|
| Semantic_Type |
Pharmacologic Substance
Antibiotic
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| UMLS_CUI | C0022020
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