Preferred Name

Recombinant Interleukin

Synonyms
Definitions

Formulated therapeutic analogs of one of a number of endogenous cytokine interleukins. Produced by T cells, macrophages, and other cells, interleukins bind to a specific surface receptor on immunohematopoietic cells, thereby inducing a multitude of biologic effects including stimulation of growth, differentiation, and proliferation of lymphocytes and eosinophils; activation of lymphocytes and macrophages; enhancement of mast cell activity; activation of the acute phase response; and stimulation of hematopoiesis. Some interleukins may enhance the host's immune response to malignant cells by stimulating lymphokine-activated killer (LAK) cells and tumor-infiltrating lymphocytes (TIL), which are capable of lysing some tumor cells. (NCI04)

ID

http://purl.obolibrary.org/obo/NCIT_C593

code

C593

definition

Formulated therapeutic analogs of one of a number of endogenous cytokine interleukins. Produced by T cells, macrophages, and other cells, interleukins bind to a specific surface receptor on immunohematopoietic cells, thereby inducing a multitude of biologic effects including stimulation of growth, differentiation, and proliferation of lymphocytes and eosinophils; activation of lymphocytes and macrophages; enhancement of mast cell activity; activation of the acute phase response; and stimulation of hematopoiesis. Some interleukins may enhance the host's immune response to malignant cells by stimulating lymphokine-activated killer (LAK) cells and tumor-infiltrating lymphocytes (TIL), which are capable of lysing some tumor cells. (NCI04)

label

Recombinant Interleukin

Legacy Concept Name

Therapeutic_Interleukin

Preferred_Name

Recombinant Interleukin

prefixIRI

NCIT:C593

prefLabel

Recombinant Interleukin

Semantic_Type

Amino Acid, Peptide, or Protein

Pharmacologic Substance

UMLS_CUI

C1527200

subClassOf

http://purl.obolibrary.org/obo/NCIT_C1283

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