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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C587
http://purl.obolibrary.org/obo/NCIT_C587
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|---|---|
| Preferred Name | Recombinant Interleukin-2 |
| Definitions |
Any recombinant analog of endogenous interleukin-2 (IL-2), a cytokine involved in intercellular communication related to cell differentiation, proliferation, inflammation, hematopoiesis, neuronal functions, and release of hormones. IL-2 binds to and activates specific receptors, triggering expression of specific genes, and may induce T cell-mediated tumor regression in some tumor types.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Any recombinant analog of endogenous interleukin-2 (IL-2), a cytokine involved in intercellular communication related to cell differentiation, proliferation, inflammation, hematopoiesis, neuronal functions, and release of hormones. IL-2 binds to and activates specific receptors, triggering expression of specific genes, and may induce T cell-mediated tumor regression in some tumor types. |
|---|---|
| prefLabel | Recombinant Interleukin-2
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| label | Recombinant Interleukin-2
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| code | C587
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| Has_Target | |
| prefixIRI | NCIT:C587
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| in_subset | |
| Preferred_Name | Recombinant Interleukin-2
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| FDA_UNII_Code | FNO32LO217
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| Contributing_Source | FDA
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| Maps_To | Recombinant Interleukin-2
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| NSC Number | 373364
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| Legacy Concept Name | Therapeutic_Interleukin-2
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| type | |
| ALT_DEFINITION | One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-2 is made by a type of T lymphocyte. It increases the growth and activity of other T lymphocytes and B lymphocytes, and affects the development of the immune system. Aldesleukin (interleukin-2 made in the laboratory) is being used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-2 is a type of cytokine.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| Accepted_Therapeutic_Use_For | Colorectal cancer; metastatic melanoma; metastatic renal cell carcinoma; Non-Hodgkins lymphoma
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0919268
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