Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C583
http://purl.obolibrary.org/obo/NCIT_C583
Preferred Name

Recombinant Interferon Gamma
Definitions
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. (NCI04)
prefLabel
Recombinant Interferon Gamma
label
Recombinant Interferon Gamma
PDQ_Closed_Trial_Search_ID
40469
code
C583
prefixIRI
NCIT:C583
in_subset
Display_Name
Recombinant Interferon Gamma
Preferred_Name
Recombinant Interferon Gamma
FDA_UNII_Code
P050J5FWC5
Contributing_Source
CTRP
FDA
Maps_To
Recombinant Interferon Gamma
CAS_Registry
82115-62-6
NSC Number
600662
635256
NCI_Drug_Dictionary_ID
40469
Legacy Concept Name
Therapeutic_Interferon_Gamma
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
40469
Accepted_Therapeutic_Use_For
Chronic granulomatous disease; Osteopetrosis
Semantic_Type
Amino Acid, Peptide, or Protein
Pharmacologic Substance
UMLS_CUI
C3539881
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