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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C576
http://purl.obolibrary.org/obo/NCIT_C576
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|---|---|
| Preferred Name | Indomethacin |
| Definitions |
A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis. (NCI04) |
|---|---|
| prefLabel | Indomethacin
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| label | Indomethacin
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| Has_Salt_Form | |
| CHEBI_ID | CHEBI:49662
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| PDQ_Closed_Trial_Search_ID | 39489
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| code | C576
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| Has_Target | |
| prefixIRI | NCIT:C576
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| in_subset |
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| Display_Name | Indomethacin
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| Preferred_Name | Indomethacin
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| FDA_UNII_Code | XXE1CET956
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C19H16ClNO4
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| Maps_To | Indomethacin
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| CAS_Registry | 53-86-1
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| NSC Number | 77541
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| NCI_Drug_Dictionary_ID | 39489
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| Legacy Concept Name | Indomethacin
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| type | |
| ALT_DEFINITION | A drug that reduces pain, fever, swelling, and redness. It is also being used to reduce tumor-induced suppression of the immune system and to increase the effectiveness of anticancer drugs. It is a type of nonsteroidal anti-inflammatory drug (NSAID).
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39489
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| Accepted_Therapeutic_Use_For | Dysmennorhea; Inflammatory disorders; Pain
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0021246
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