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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C564
http://purl.obolibrary.org/obo/NCIT_C564
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|---|---|
| Preferred Name | Ifosfamide |
| Definitions |
A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. (NCI04) |
|---|---|
| prefLabel | Ifosfamide
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| label | Ifosfamide
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| CHEBI_ID | CHEBI:5864
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| PDQ_Closed_Trial_Search_ID | 40024
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| code | C564
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| prefixIRI | NCIT:C564
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| in_subset |
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| Display_Name | Ifosfamide
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| Preferred_Name | Ifosfamide
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| FDA_UNII_Code | UM20QQM95Y
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| Contributing_Source |
CTRP
FDA
PCDC
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| Chemical_Formula | C7H15Cl2N2O2P
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| Maps_To | Ifosfamide
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| CAS_Registry | 3778-73-2
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| NSC Number | 109724
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| NCI_Drug_Dictionary_ID | 40024
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| Legacy Concept Name | Ifosfamide
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| Is_PCDC_GCT_Permissible_Value_For_Variable | |
| type | |
| ALT_DEFINITION | A drug that is used with other drugs to treat germ cell testicular cancer that did not respond to previous treatment with other drugs. It is also being studied in the treatment of other types of cancer. Ifex attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent and a type of antimetabolite.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 40024
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| Accepted_Therapeutic_Use_For | Breast cancer; gastric carcinoma; lung cancer; lymphocytic leukemias; lymphoma; Hodgkins and Non-Hodgkins; ovarian cancer; pancreatic carcinoma; sarcomas; testicular cancer
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0020823
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