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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C562
http://purl.obolibrary.org/obo/NCIT_C562
|
|---|---|
| Preferred Name | Idarubicin |
| Definitions |
A semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin. Idarubicin intercalates into DNA and interferes with the activity of topoisomerase II, thereby inhibiting DNA replication, RNA transcription and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin. Idarubicin intercalates into DNA and interferes with the activity of topoisomerase II, thereby inhibiting DNA replication, RNA transcription and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds. |
|---|---|
| prefLabel | Idarubicin
|
| label | Idarubicin
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| Has_Salt_Form | |
| CHEBI_ID | CHEBI:42068
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| PDQ_Closed_Trial_Search_ID | 39753
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| code | C562
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| Has_Target | |
| prefixIRI | NCIT:C562
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| in_subset |
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| Display_Name | Idarubicin
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| Preferred_Name | Idarubicin
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| FDA_UNII_Code | ZRP63D75JW
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| Is_PCDC_AML_Permissible_Value_For_Variable | |
| Contributing_Source |
CTRP
FDA
PCDC
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| Chemical_Formula | C26H27NO9
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| Maps_To | Idarubicin
|
| CAS_Registry | 58957-92-9
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| NCI_Drug_Dictionary_ID | 39753
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| Legacy Concept Name | Idarubicin
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called antitumor antibiotics.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39753
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| Accepted_Therapeutic_Use_For | Acute myeloid leukemia; acute nonlymphocytic leukemia
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
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| UMLS_CUI | C0020789
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| Delete | Subject | Author | Type | Created |
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