Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
Jump to:
| Preferred Name | Hydroxamic Acids | |
| Synonyms |
|
|
| Definitions |
A group of weak acids with the general chemical formula RC(=O)N(R')OH and antineoplastic and antimicrobial activities. Hydroxamic acids covalently bind to the zinc(II) ion in the active sites of matrix metalloproteinases (MMP), thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C556 |
|
| CHEBI_ID |
CHEBI:24650
|
|
| code |
C556
|
|
| definition |
A group of weak acids with the general chemical formula RC(=O)N(R')OH and antineoplastic and antimicrobial activities. Hydroxamic acids covalently bind to the zinc(II) ion in the active sites of matrix metalloproteinases (MMP), thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. (NCI04)
|
|
| label |
Hydroxamic Acids
|
|
| Legacy Concept Name |
Hydroxamic_Acids
|
|
| Preferred_Name |
Hydroxamic Acids
|
|
| prefixIRI |
NCIT:C556
|
|
| prefLabel |
Hydroxamic Acids
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
|
|
| UMLS_CUI |
C0020314
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
Create mapping