Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C546 http://purl.obolibrary.org/obo/NCIT_C546
Preferred Name	Pibenzimol
Definitions	A fluorescent dye of benzimidazole derivative. Pibenzimol binds to AT-specific sites in the minor groove of duplex DNA and inhibits topoisomerase I, and DNA polymerase, thereby preventing DNA replication. This agent prolongs the G2 phase of the cell cycle and initiates apoptosis in tumor cells. (NCI04)
Type	http://www.w3.org/2002/07/owl#Class

definition	A fluorescent dye of benzimidazole derivative. Pibenzimol binds to AT-specific sites in the minor groove of duplex DNA and inhibits topoisomerase I, and DNA polymerase, thereby preventing DNA replication. This agent prolongs the G2 phase of the cell cycle and initiates apoptosis in tumor cells. (NCI04)
prefLabel	Pibenzimol
label	Pibenzimol
CHEBI_ID	CHEBI:52082
PDQ_Closed_Trial_Search_ID	39193
code	C546
prefixIRI	NCIT:C546
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Preferred_Name	Pibenzimol
FDA_UNII_Code	LHQ7J5KV9B
Contributing_Source	FDA
Chemical_Formula	C25H24N6O
Maps_To	Pibenzimol
CAS_Registry	23491-45-4
NSC Number	322921
NCI_Drug_Dictionary_ID	39193
Legacy Concept Name	Pibenzimol
type	http://www.w3.org/2002/07/owl#Class
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C2115 http://purl.obolibrary.org/obo/NCIT_C1904
PDQ_Open_Trial_Search_ID	39193
Semantic_Type	Organic Chemical Pharmacologic Substance
UMLS_CUI	C0019832

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