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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C544
http://purl.obolibrary.org/obo/NCIT_C544
|
|---|---|
| Preferred Name | Altretamine |
| Definitions |
A synthetic cytotoxic s-triazine derivative similar in structure to alkylating agent triethylenemelamin with antineoplastic activity. Although the precise mechanism by which altretamine exerts its cytotoxic effect is unknown, N-demethylation of altretamine may produce reactive intermediates which covalently bind to DNA, resulting in DNA damage. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic cytotoxic s-triazine derivative similar in structure to alkylating agent triethylenemelamin with antineoplastic activity. Although the precise mechanism by which altretamine exerts its cytotoxic effect is unknown, N-demethylation of altretamine may produce reactive intermediates which covalently bind to DNA, resulting in DNA damage. (NCI04) |
|---|---|
| prefLabel | Altretamine
|
| label | Altretamine
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| CHEBI_ID | CHEBI:24564
|
| PDQ_Closed_Trial_Search_ID | 39475
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| code | C544
|
| prefixIRI | NCIT:C544
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| in_subset | |
| Preferred_Name | Altretamine
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| FDA_UNII_Code | Q8BIH59O7H
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| Contributing_Source | FDA
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| Chemical_Formula | C9H18N6
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| Maps_To | Altretamine
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| CAS_Registry | 645-05-6
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| NSC Number | 13875
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| NCI_Drug_Dictionary_ID | 39475
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| Legacy Concept Name | Altretamine
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called alkylating agents.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39475
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0019453
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