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Biological and Environmental Research Ontology
| Preferred Name | Bemiparin Sodium | |
| Synonyms |
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| Definitions |
The sodium salt of bemiparin, a second generation, synthetic, low-molecular-weight heparin (LMWH) with anticoagulant activity. Derived, after depolymerisation and fractionation, from medical-grade porcine unfractionated heparin (UFH), bemiparin has an average molecular weight of 3,600 daltons and has a higher anti-factor Xa/anti-factor IIa ratio (8:1) than first-generation LMWHs. This anticoagulant binds to antithrombin III, thereby enhancing the inactivation of activated factor X (Factor Xa) and, to a lesser extent, activated factor II (Factor IIa). Compared to unfractionated heparins, the use of bemiparin is associated with lower incidences of major bleeding, osteoporosis, and heparin-induced thrombocytopenia. Bemiparin also promotes a greater release of tissue factor pathway inhibitor than UFH or dalteparin. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C53400 |
|
| code |
C53400
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|
| Contributing_Source |
FDA
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|
| definition |
The sodium salt of bemiparin, a second generation, synthetic, low-molecular-weight heparin (LMWH) with anticoagulant activity. Derived, after depolymerisation and fractionation, from medical-grade porcine unfractionated heparin (UFH), bemiparin has an average molecular weight of 3,600 daltons and has a higher anti-factor Xa/anti-factor IIa ratio (8:1) than first-generation LMWHs. This anticoagulant binds to antithrombin III, thereby enhancing the inactivation of activated factor X (Factor Xa) and, to a lesser extent, activated factor II (Factor IIa). Compared to unfractionated heparins, the use of bemiparin is associated with lower incidences of major bleeding, osteoporosis, and heparin-induced thrombocytopenia. Bemiparin also promotes a greater release of tissue factor pathway inhibitor than UFH or dalteparin.
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| FDA_UNII_Code |
P59JKU02CE
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 |
|
| label |
Bemiparin Sodium
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| Legacy Concept Name |
Bemiparin_Sodium
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| NCI_Drug_Dictionary_ID |
463367
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| PDQ_Closed_Trial_Search_ID |
463367
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|
| PDQ_Open_Trial_Search_ID |
463367
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| Preferred_Name |
Bemiparin Sodium
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| prefixIRI |
NCIT:C53400
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| prefLabel |
Bemiparin Sodium
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C1529923
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| subClassOf |
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