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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C53398
http://purl.obolibrary.org/obo/NCIT_C53398
|
|---|---|
| Preferred Name | Dacomitinib |
| Definitions |
A highly selective, orally bioavailable small-molecule inhibitor of the HER family of tyrosine kinases with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human Her-1, Her-2, and Her-4, resulting in the proliferation inhibition and apoptosis of tumor cells that overexpress these receptors.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A highly selective, orally bioavailable small-molecule inhibitor of the HER family of tyrosine kinases with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human Her-1, Her-2, and Her-4, resulting in the proliferation inhibition and apoptosis of tumor cells that overexpress these receptors. |
|---|---|
| prefLabel | Dacomitinib
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| label | Dacomitinib
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| PDQ_Closed_Trial_Search_ID | 462567
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| code | C53398
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| Has_Target | |
| prefixIRI | NCIT:C53398
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| in_subset |
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| Display_Name | Dacomitinib
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| Preferred_Name | Dacomitinib
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| FDA_UNII_Code | 5092U85G58
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C24H25ClFN5O2.H2O
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| Maps_To | Dacomitinib
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| CAS_Registry | 1042385-75-0
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| NCI_Drug_Dictionary_ID | 462567
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| Legacy Concept Name | PF-00299804
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| type | |
| ALT_DEFINITION | A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called protein tyrosine kinase inhibitors.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 462567
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| Accepted_Therapeutic_Use_For | metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 19 deletion or exon 21 L858R substitution mutations
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1709400
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| Delete | Subject | Author | Type | Created |
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