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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C529
http://purl.obolibrary.org/obo/NCIT_C529
|
|---|---|
| Preferred Name | Gossypol |
| Definitions |
An orally-active polyphenolic aldehyde with potential antineoplastic activity. Derived primarily from unrefined cottonseed oil, gossypol induces cell cycle arrest at the G0/G1 phase, thereby inhibiting DNA replication and inducing apoptosis. This agent also inhibits cell-signaling enzymes, resulting in inhibition of cell growth, and may act as a male contraceptive.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally-active polyphenolic aldehyde with potential antineoplastic activity. Derived primarily from unrefined cottonseed oil, gossypol induces cell cycle arrest at the G0/G1 phase, thereby inhibiting DNA replication and inducing apoptosis. This agent also inhibits cell-signaling enzymes, resulting in inhibition of cell growth, and may act as a male contraceptive. |
|---|---|
| prefLabel | Gossypol
|
| label | Gossypol
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| Has_Salt_Form | |
| CHEBI_ID | CHEBI:28584
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| PDQ_Closed_Trial_Search_ID | 505287
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| code | C529
|
| prefixIRI | NCIT:C529
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| in_subset | |
| Preferred_Name | Gossypol
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| FDA_UNII_Code | KAV15B369O
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| Contributing_Source | FDA
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| Chemical_Formula | C30H30O8
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| Maps_To | Gossypol
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| CAS_Registry | 303-45-7
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| NSC Number |
56817
624336
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| NCI_Drug_Dictionary_ID | 505287
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| Legacy Concept Name | Gossypol
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of several types of cancer. It comes from the seed of the cotton plant (Gossypium). It blocks the growth of cells and may kill cancer cells. Cottonseed meal toxin may also act as a male contraceptive (a type of birth control).
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 505287
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0018096
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