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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C52199
http://purl.obolibrary.org/obo/NCIT_C52199
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|---|---|
| Preferred Name | KSP Inhibitor SB-743921 |
| Definitions |
A synthetic small molecule with potential antineoplastic properties. SB-743921 selectively inhibits kinesin spindle protein (KSP), an important protein involved in the early stages of mitosis that is expressed in proliferating cells. Inhibition of KSP results in inhibition of mitotic spindle assembly and interrupts cell division, thereby causing cell cycle arrest and induction of apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic small molecule with potential antineoplastic properties. SB-743921 selectively inhibits kinesin spindle protein (KSP), an important protein involved in the early stages of mitosis that is expressed in proliferating cells. Inhibition of KSP results in inhibition of mitotic spindle assembly and interrupts cell division, thereby causing cell cycle arrest and induction of apoptosis. |
|---|---|
| prefLabel | KSP Inhibitor SB-743921
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| label | KSP Inhibitor SB-743921
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| PDQ_Closed_Trial_Search_ID | 456262
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| code | C52199
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| Has_Target | |
| prefixIRI | NCIT:C52199
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| in_subset |
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| Display_Name | SB-743921
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| Preferred_Name | KSP Inhibitor SB-743921
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| FDA_UNII_Code | 24DSZ1VN92
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| Contributing_Source |
CTRP
FDA
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| Maps_To | KSP Inhibitor SB-743921
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| CAS_Registry | 618430-39-0
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| NCI_Drug_Dictionary_ID | 456262
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| Legacy Concept Name | SB-743921
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 456262
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1709979
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