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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C52185
http://purl.obolibrary.org/obo/NCIT_C52185
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|---|---|
| Preferred Name | Alpha V Beta 1 Inhibitor ATN-161 |
| Definitions |
A small peptide antagonist of integrin alpha5beta1 with potential antineoplastic activity. ATN-161 selectively binds to and blocks the receptor for integrin alpha5beta1, thereby preventing integrin alpha5beta1 binding. This receptor blockade may result in inhibition of endothelial cell-cell interactions, endothelial cell-matrix interactions, angiogenesis, and tumor progression. Integrin alpha5beta1 is expressed on endothelial cells and plays a crucial role in endothelial cell adhesion and migration.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A small peptide antagonist of integrin alpha5beta1 with potential antineoplastic activity. ATN-161 selectively binds to and blocks the receptor for integrin alpha5beta1, thereby preventing integrin alpha5beta1 binding. This receptor blockade may result in inhibition of endothelial cell-cell interactions, endothelial cell-matrix interactions, angiogenesis, and tumor progression. Integrin alpha5beta1 is expressed on endothelial cells and plays a crucial role in endothelial cell adhesion and migration. |
|---|---|
| prefLabel | Alpha V Beta 1 Inhibitor ATN-161
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| label | Alpha V Beta 1 Inhibitor ATN-161
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| PDQ_Closed_Trial_Search_ID | 459774
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| code | C52185
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| prefixIRI | NCIT:C52185
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| in_subset | |
| Preferred_Name | Alpha V Beta 1 Inhibitor ATN-161
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| FDA_UNII_Code | XW0H5LE42K
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| Contributing_Source | FDA
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| Maps_To | Alpha V Beta 1 Inhibitor ATN-161
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| CAS_Registry | 262438-43-7
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| NCI_Drug_Dictionary_ID | 459774
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| Legacy Concept Name | ATN-161
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of some types of cancer. ATN-161 may prevent the spread of tumor cells and may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 459774
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1706674
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