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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C513
http://purl.obolibrary.org/obo/NCIT_C513
|
|---|---|
| Preferred Name | Tegafur |
| Definitions |
A congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme. Subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by inhibiting thymidylate synthase and reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme. Subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by inhibiting thymidylate synthase and reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate. (NCI04) |
|---|---|
| label | Tegafur
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| prefLabel | Tegafur
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| Legacy Concept Name | Tegafur
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| in_subset | |
| Preferred_Name | Tegafur
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| Is_Value_For_GDC_Property | |
| Chemical_Formula | C8H9FN2O3
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| Maps_To | Tegafur
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| PDQ_Open_Trial_Search_ID | 39248
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| UMLS_CUI | C0016778
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| FDA_UNII_Code | 1548R74NSZ
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| prefixIRI | NCIT:C513
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| NCI_Drug_Dictionary_ID | 39248
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| Contributing_Source | FDA
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| subClassOf | |
| code | C513
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called antimetabolites.
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| NSC Number | 148958
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| PDQ_Closed_Trial_Search_ID | 39248
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| CAS_Registry | 17902-23-7
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