Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C504
http://purl.obolibrary.org/obo/NCIT_C504
Preferred Name

Floxuridine
Definitions
A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04)
prefLabel
Floxuridine
label
Floxuridine
CHEBI_ID
CHEBI:60761
PDQ_Closed_Trial_Search_ID
39242
code
C504
prefixIRI
NCIT:C504
in_subset
Display_Name
Floxuridine
Preferred_Name
Floxuridine
FDA_UNII_Code
039LU44I5M
Contributing_Source
CTRP
FDA
Chemical_Formula
C9H11FN2O5
Maps_To
Floxuridine
CAS_Registry
50-91-9
NSC Number
27640
NCI_Drug_Dictionary_ID
39242
Legacy Concept Name
Floxuridine
type
ALT_DEFINITION
A drug used in the treatment of cancer. It is a type of antimetabolite.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
39242
Accepted_Therapeutic_Use_For
Gastrointestinal adenocarcinoma metastatic to the liver
Semantic_Type
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
UMLS_CUI
C0016343
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