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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C49176
http://purl.obolibrary.org/obo/NCIT_C49176
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|---|---|
| Preferred Name | Palbociclib |
| Definitions |
An orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression. |
|---|---|
| prefLabel | Palbociclib
|
| label | Palbociclib
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| PDQ_Closed_Trial_Search_ID | 454586
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| code | C49176
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| prefixIRI | NCIT:C49176
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| in_subset |
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| Display_Name | Palbociclib
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| Preferred_Name | Palbociclib
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| FDA_UNII_Code | G9ZF61LE7G
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C24H29N7O2
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| Maps_To | Palbociclib
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| CAS_Registry | 571190-30-2
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| NCI_Drug_Dictionary_ID | 454586
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| Legacy Concept Name | PD-0332991
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 454586
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| Accepted_Therapeutic_Use_For | hormone receptor (HR) positive, human epidermal growth factor receptor 2 (HER2) negative advanced or metastatic breast cancer
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C3853822
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