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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C49175
http://purl.obolibrary.org/obo/NCIT_C49175
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|---|---|
| Preferred Name | Notch Signaling Pathway Inhibitor MK0752 |
| Definitions |
A synthetic small molecule with potential antineoplastic activity. MK0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated. The Notch signaling pathway plays an important role in cell-fate determination, cell survival, and cell proliferation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic small molecule with potential antineoplastic activity. MK0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated. The Notch signaling pathway plays an important role in cell-fate determination, cell survival, and cell proliferation. |
|---|---|
| prefLabel | Notch Signaling Pathway Inhibitor MK0752
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| label | Notch Signaling Pathway Inhibitor MK0752
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| PDQ_Closed_Trial_Search_ID | 446541
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| code | C49175
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| prefixIRI | NCIT:C49175
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| in_subset |
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| Display_Name | Notch Signaling Pathway Inhibitor MK0752
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| Preferred_Name | Notch Signaling Pathway Inhibitor MK0752
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| FDA_UNII_Code | 9JD9B4S53T
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Notch Signaling Pathway Inhibitor MK0752
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| CAS_Registry | 471905-41-6
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| NCI_Drug_Dictionary_ID | 446541
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| Legacy Concept Name | MK0752
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of cancer. It blocks signals between growing cells and may kill cancer cells. It is a type of signal transduction inhibitor.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 446541
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C1708824
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